Beclin-1 (5C2) Mouse Monoclonal Antibody
Product Specifications
Background
Beclin 1 (BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], function:Plays a central role in autophagy (By similarity) . May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus., similarity:Belongs to the beclin family., subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells., subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity) . Interacts with BCL2 and BCL2L1., tissue specificity:Ubiquitous.
Product Name Alternative
BECN1
Gene Name
BECN1
Gene ID
8678
Swiss Prot
Q14457
Host
Mouse
Reactivity
Human, Rat, Mouse, Bovine
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF
Field of Research
Regulation of autophagy
Purification
Affinity purification
Dilution
WB 1:1000-1:2000, IHC 1:100-1:200, ICC/IF 1:50-1:200
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
60kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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