Beclin-1 (5C2) Mouse Monoclonal Antibody

Beclin 1 (BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], function:Plays a central role in autophagy (By similarity) . May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus., similarity:Belongs to the beclin family., subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells., subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity) . Interacts with BCL2 and BCL2L1., tissue specificity:Ubiquitous.