NBR1 (7C3) Mouse Monoclonal Antibody
Product Specifications
Background
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014], caution:Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125., domain:The OPR domain mediates interaction with SQSTM1., similarity:Contains 1 OPR domain., similarity:Contains 1 UBA domain., similarity:Contains 1 ZZ-type zinc finger., subunit:Homooligomer and heterooligomer. Interacts with SQSTM1, titin/TTN and RNF29.
Product Name Alternative
Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein) (Membrane component chromosome 17 surface marker 2) (Neighbor of BRCA1 gene 1 protein) (Protein 1A1-3B)
Gene Name
NBR1
Gene ID
4077
Swiss Prot
Q14596
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
IHC, ICC/IF
Purification
Affinity purification
Dilution
IHC 1:50-1:300, ICC/IF 1:50-1:200
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
120kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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