MICU1 (Mix) Mouse Monoclonal Antibody
Product Specifications
Background
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2013], allergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations., function:Induces T helper 1-mediated autoreactivity, which is accompanied by the release of IFNG., sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part., similarity:Contains 2 EF-hand domains., tissue specificity:Expressed in epithelial cell line. Strongly expressed in epidermal keratinocytes and dermal endothelial cells.
Product Name Alternative
Calcium uptake protein 1, mitochondrial; Atopy-related autoantigen CALC; ara CALC; Calcium-binding atopy-related autoantigen 1; allergen Hom s 4
Gene Name
MICU1
Gene ID
10367
Swiss Prot
Q9BPX6
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF
Purification
Affinity purification
Dilution
WB 1:1000-1:2000, IHC 1:100-1:200, ICC/IF 1:100-1:200
Form
Liquid
Buffer
PBS, pH 7.4, containing 0.5%BSA, 0.02% New type preservative N as Preservative and 50% Glycerol.
Modification
Unmodified
Molecular Weight
55kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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