Phospho-JAK2 (Tyr1007) Rabbit Polyclonal Antibody
Product Specifications
Background
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
Product Name Alternative
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Gene Name
JAK2
Gene ID
3717
Swiss Prot
O60674
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ELISA
Field of Research
Cell Biology
Purification
Affinity Purification
Dilution
WB 1:500-1:1000, IHC 1:50-1:100, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Modification
Phosphorylated
Molecular Weight
Calculated MW: 131 kDa; Observed MW: 131 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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