Gab 1 (phospho Tyr659) Rabbit Polyclonal Antibody

GRB2 associated binding protein 1 (GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008], function:Probably involved in EGF and insulin receptor signaling., PTM:Phosphorylated on tyrosine residue (s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) . Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains., similarity:Belongs to the GAB family., similarity:Contains 1 PH domain., subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.