Gab 1 (phospho Tyr659) Rabbit Polyclonal Antibody
Product Specifications
Background
GRB2 associated binding protein 1 (GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008], function:Probably involved in EGF and insulin receptor signaling., PTM:Phosphorylated on tyrosine residue (s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) . Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains., similarity:Belongs to the GAB family., similarity:Contains 1 PH domain., subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.
Product Name Alternative
GAB1; GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1
Gene Name
GAB1
Gene ID
2549
Swiss Prot
Q13480
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
ErbB_HER; Neurotrophin; Renal cell carcinoma
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:5000-1:10000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Molecular Weight
76kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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