KPI-2 Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5) /p35 complex. This protein involves in nerve growth factor (NGF) -TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009], catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Phosphorylates PPP1C, phosphorylase b and CFTR., online information:LMTK2 entry, PTM:Autophosphorylated. Phosphorylated., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Contains 1 protein kinase domain., subunit:Interacts with PPP1C and inhibitor-2., tissue specificity:Mainly expressed in skeletal muscle, and weakly in brain and pancreas.

LMTK2; AATYK2; BREK; KIAA1079; KPI2; LMR2; Serine/threonine-protein kinase LMTK2; Apoptosis-associated tyrosine kinase 2; Brain-enriched kinase; hBREK; CDK5/p35-regulated kinase; CPRK; Kinase/phosphatase/inhibitor 2; Lemur tyrosine kinase 2