Integrin α1 Rabbit Polyclonal Antibody

Integrin subunit alpha 1 (ITGA1) Homo sapiens This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008], domain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage., function:Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen., similarity:Belongs to the integrin alpha chain family., similarity:Contains 1 VWFA domain., similarity:Contains 7 FG-GAP repeats., subunit:Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.

Focal adhesion; ECM-receptor interaction; Hematopoietic cell lineage; Regulates Actin and Cytoskeleton; Hypertrophic cardiomyopathy (HCM) ; Arrhythmogenic right ventricular cardiomyopathy (ARVC) ; Dilated cardiomyopathy