Crk-L (phospho Tyr207) Rabbit Polyclonal Antibody

This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009], function:May mediate the transduction of intracellular signals., similarity:Contains 1 SH2 domain., similarity:Contains 2 SH3 domains., subunit:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.

MAPK_ERK_Growth; MAPK_G_Protein; ErbB_HER; Chemokine; Focal adhesion; Fc gamma R-mediated phagocytosis; Neurotrophin; Regulates Actin and Cytoskeleton; Insulin_Receptor; Pathways in cancer; Renal cell carcinoma; Chronic myeloid leukemia