Crk-L (phospho Tyr207) Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009], function:May mediate the transduction of intracellular signals., similarity:Contains 1 SH2 domain., similarity:Contains 2 SH3 domains., subunit:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.
Product Name Alternative
CRKL; Crk-like protein
Gene Name
CRKL
Gene ID
1399
Swiss Prot
P46109
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
MAPK_ERK_Growth; MAPK_G_Protein; ErbB_HER; Chemokine; Focal adhesion; Fc gamma R-mediated phagocytosis; Neurotrophin; Regulates Actin and Cytoskeleton; Insulin_Receptor; Pathways in cancer; Renal cell carcinoma; Chronic myeloid leukemia
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:200-1:1000, ELISA 1:5000-1:10000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Molecular Weight
39kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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