PLC β3 (phospho Ser537) Rabbit Polyclonal Antibody

This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H (2) O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol., cofactor:Calcium., function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes., similarity:Contains 1 C2 domain., similarity:Contains 1 PI-PLC X-box domain., similarity:Contains 1 PI-PLC Y-box domain., subunit:Interacts with SHANK2 (By similarity) . Interacts with LPAR2.