PLC β3 (phospho Ser537) Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H (2) O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol., cofactor:Calcium., function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes., similarity:Contains 1 C2 domain., similarity:Contains 1 PI-PLC X-box domain., similarity:Contains 1 PI-PLC Y-box domain., subunit:Interacts with SHANK2 (By similarity) . Interacts with LPAR2.
Product Name Alternative
PLCB3; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3
Gene Name
PLCB3
Gene ID
5331
Swiss Prot
Q01970
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
Stem cell pathway; WNT; WNT-T CELL; β-Catenin; AMPK
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Molecular Weight
150kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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