Akt2 (phospho Ser474) Rabbit Polyclonal Antibody

This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a protein = ADP + a phosphoprotein., disease:Alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas., enzyme regulation:Two specific sites, one in the kinase domain (Thr-309) and the other in the C-terminal regulatory region (Ser-474), need to be phosphorylated for its full activation., function:General protein kinase capable of phosphorylating several known proteins., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 PH domain., similarity:Contains 1 protein kinase domain., subunit:Interacts (via PH domain) with MTCP1, TCL1A AND TCL1B., tissue specificity:In all human cell types so far analyzed.

Regulation_Microtubule; Stem cell pathway; T_Cell_Receptor; Regulates Angiogenesis; Insulin Receptor; Toll_Like; ErbB/HER; AMPK; MAPK_ERK_Growth; MAPK_G_Protein; B_Cell_Antigen; Adherens_Junction; PI3K/Akt; mTOR