IL-2 Rabbit Polyclonal Antibody

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7) . The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008], disease:A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL) . Translocation t (4;16) (q26; p13) with involves TNFRSF17., function:Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells., online information:Interleukin-2 entry, online information:The Singapore human mutation and polymorphism database, pharmaceutical:Available under the name Proleukin (Chiron) . Used in patients with renal cell carcinoma or metastatic melanoma., similarity:Belongs to the IL-2 family.

Cytokine-cytokine receptor interaction; Jak_STAT; T_Cell_Receptor; Intestinal immune network for IgA production; Type I diabetes mellitus; Autoimmune thyroid disease; Allograft rejection; Graft-versus-host disease