CLIC4 Rabbit Polyclonal Antibody

Chloride intracellular channel 4 (CLIC4) Homo sapiens Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits a intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells) . [provided by RefSeq, Jul 2008], domain:Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion., function:Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. May play a role in angiogenesis., induction:Up-regulated by calcium ions in differentiating keratinocytes., similarity:Belongs to the chloride channel CLIC family., similarity:Contains 1 GST C-terminal domain., subcellular location:Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles., subunit:Monomer. Interacts with HRH3., tissue specificity:Detected in epithelial cells from colon, esophagus and kidney (at protein level) . Expression is prominent in heart, placenta and skeletal muscle.