APLP-1 Rabbit Polyclonal Antibody

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008], domain:The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis., function:May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity) . Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I., function:The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis., miscellaneous:Binds zinc and copper in the extracellular domain. Zinc-binding increases heparin binding. No Cu (2+) reducing activity with copper-binding., PTM:N- and O-glycosylated., PTM:Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3., similarity:Belongs to the APP family., subcellular location:C-terminally processed in the Golgi complex., subunit:Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB and APBA family members, MAPK8IP1 and Dab1 (By similarity) . Binding to Dab1 inhibits its serine phosphorylation (By similarity) . Interacts with CPEB1., tissue specificity:Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD) .