Fatty Acid Synthase Rabbit Polyclonal Antibody

The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008], catalytic activity: (3R) -3-hydroxyacyl-[acyl-carrier-protein] + NADP (+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH., catalytic activity: (3R) -3-hydroxypalmitoyl-[acyl-carrier-protein] = hexadec-2-enoyl-[acyl-carrier-protein] + H (2) O., catalytic activity:Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein]., catalytic activity:Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO (2) + 2n NADP (+) ., catalytic activity:Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO (2) + [acyl-carrier-protein]., catalytic activity:Acyl-[acyl-carrier-protein] + NADP (+) = trans-2,3-dehydroacyl-[acyl-carrier-protein] + NADPH., catalytic activity:Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein]., catalytic activity:Oleoyl-[acyl-carrier-protein] + H (2) O = [acyl-carrier-protein] + oleate., function:Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein., miscellaneous:The relatively low beta-ketoacyl synthase activity may be attributable to the low 4'-phosphopantetheine content of the protein., sequence caution:Several sequencing errors., similarity:Contains 1 acyl carrier domain., subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV., subunit:Homodimer which is arranged in a head to tail fashion., tissue specificity:Ubiquitous. Prominent expression in brain, lung, and liver.