SCML2 Rabbit Polyclonal Antibody

This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010], function:Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the SCM family., similarity:Contains 1 SAM (sterile alpha motif) domain., similarity:Contains 2 MBT repeats., tissue specificity:Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.