NUMB Rabbit Polyclonal Antibody
Product Specifications
Background
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], function:Implicated in the control of cell fate decisions during development., PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity) . Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation., sequence caution:Intron retention., similarity:Contains 1 PID domain., subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.
Product Name Alternative
NUMB; Protein numb homolog; h-Numb; Protein S171
Gene Name
NUMB
Gene ID
8650
Swiss Prot
P49757
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, ICC/IF, ELISA
Field of Research
Notch
Purification
Affinity purification
Dilution
WB 1:500-1:2000, ICC/IF 1:100-1:500, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
70kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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