NUMB Rabbit Polyclonal Antibody

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016], function:Implicated in the control of cell fate decisions during development., PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity) . Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation., sequence caution:Intron retention., similarity:Contains 1 PID domain., subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.