Tcl1 Rabbit Polyclonal Antibody

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR) -alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]) . In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]) .[supplied by OMIM, Jul 2010], disease:Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL) . Translocation t (14;14) (q11; q32) ; translocation t (7;14) (q35; q32) ; inversion inv (14) (q11; q32) that involves the T-cell receptor alpha/delta locuses., function:Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival., similarity:Belongs to the TCL1 family., subcellular location:Microsomal fraction., subunit:Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain) . Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity., tissue specificity:Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.