CD35 Rabbit Polyclonal Antibody

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variantsfunction:Mediates cellular binding of particles and immune complexes that have activated complement., miscellaneous:This is the sequence of the F allotype of CR1., online information:Blood group antigen gene mutation database, polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl (a) /Vil (Kn4, or Swain-Langley; Vil or Villien) . Sl (a-) phenotype is more common in persons of African descent and may protect against fatal malaria., similarity:Belongs to the receptors of complement activation (RCA) family., similarity:Contains 30 Sushi (CCP/SCR) domains., subunit:Monomer., tissue specificity:Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.