ZFP91 Rabbit Polyclonal Antibody

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010], disease:Overexpressed in most acute myelogenous leukemia (AML) cases (27 over 29) ., function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy., function:May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis., online information:Ciliary neurotrophic factor entry, similarity:Belongs to the CNTF family., similarity:Belongs to the krueppel C2H2-type zinc-finger protein family., similarity:Contains 5 C2H2-type zinc fingers., subunit:Homodimer., tissue specificity:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific., tissue specificity:Nervous system.