PAR1 (Cleaved-Ser42) Rabbit Polyclonal Antibody

Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015], function:High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development., PTM:A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand., PTM:Phosphorylated; probably mediating desensitization prior to the uncoupling and internalization of the receptor., similarity:Belongs to the G-protein coupled receptor 1 family., tissue specificity:Platelets and vascular endothelial cells.