PLCB4 Rabbit Polyclonal Antibody

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010], alternative products:Additional isoforms seem to exist, catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H (2) O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol., cofactor:Calcium., function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction., similarity:Contains 1 C2 domain., similarity:Contains 1 PI-PLC X-box domain., similarity:Contains 1 PI-PLC Y-box domain., tissue specificity:Preferentially expressed in the retina.

Inositol phosphate metabolism; Calcium; Chemokine; Phosphatidylinositol signaling system; Vascular smooth muscle contraction; WNT; WNT-T CELLGap junction; Long-term potentiation; Long-term depression; GnRH; Melanogenesis; Alzheimer's disease; Huntington's disease