PIGC Rabbit Polyclonal Antibody

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized. [provided by RefSeq, Jul 2008], catalytic activity:UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6- (N-acetyl-alpha-D-glucosaminyl) -1-phosphatidyl-1D-myo-inositol., function:Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis., online information:Phosphatidylinositol N-acetylglucosaminyltransferase subunit C8, pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis., similarity:Belongs to the PIGC family., subunit:Associates with PIGA, PIGH, PIGP, PIGQ and DPM2. The latter is not essential for activity.