HIPK1 Rabbit Polyclonal Antibody

Homeodomain interacting protein kinase 1 (HIPK1) Homo sapiens The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008], catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation., PTM:Autophosphorylated. Phosphorylated and activated by JNK1., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily., similarity:Contains 1 protein kinase domain., subcellular location:Predominantly nuclear., subunit:Interacts with Nkx1-2 and Nkx2-5 (By similarity) . Interacts with DAXX and TP53., tissue specificity:Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.