GPDA Rabbit Polyclonal Antibody

This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012], catalytic activity:sn-glycerol 3-phosphate + NAD (+) = glycerone phosphate + NADH., enzyme regulation:Inhibited by zinc ions and sulfate., similarity:Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family., subunit:Homodimer.