PIGQ Rabbit Polyclonal Antibody

This gene is involved in the first step in glycosylphosphatidylinositol (GPI) -anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI) . Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012], catalytic activity:UDP-N-acetyl-D-glucosamine + 1-phosphatidyl-1D-myo-inositol = UDP + 6- (N-acetyl-alpha-D-glucosaminyl) -1-phosphatidyl-1D-myo-inositol., function:Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis., pathway:Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis., similarity:Belongs to the PIGQ family., subunit:Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity.