EDEM3 Rabbit Polyclonal Antibody

Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]) .[supplied by OMIM, Mar 2008], domain:Contains a protease-associated domain (PA) of unknown function., function:Involved in endoplasmic reticulum-associated degradation (ERAD) . Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity., PTM:N-glycosylated., similarity:Belongs to the glycosyl hydrolase 47 family., similarity:Contains 1 PA (protease associated) domain.