EDEM3 Rabbit Polyclonal Antibody
Product Specifications
Background
Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]) .[supplied by OMIM, Mar 2008], domain:Contains a protease-associated domain (PA) of unknown function., function:Involved in endoplasmic reticulum-associated degradation (ERAD) . Accelerates the glycoprotein ERAD by proteasomes. This process depends on mannose-trimming from the N-glycans. Seems to have alpha 1,2-mannosidase activity., PTM:N-glycosylated., similarity:Belongs to the glycosyl hydrolase 47 family., similarity:Contains 1 PA (protease associated) domain.
Gene Name
EDEM3 C1orf22
Gene ID
80267
Swiss Prot
Q9BZQ6
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
102kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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