PTP IA-2β Rabbit Polyclonal Antibody

This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015], catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate., disease:Autoantigen in insulin-dependent diabetes mellitus (IDDM) ., domain:The cytoplasmic domain appears to contain the autoantigenic epitopes., function:Implicated in development of nervous system and pancreatic endocrine cells., PTM:Appears to undergo multiple proteolytic cleavage at consecutive basic residues., similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily., similarity:Contains 1 tyrosine-protein phosphatase domain., tissue specificity:Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.