SPHK1 (Phospho-Ser225) Rabbit Polyclonal Antibody

Catalytic activity:ATP + sphinganine = ADP + sphinganine 1-phosphate., catalytic activity:ATP + sphingosine = ADP + sphingosine 1-phosphate., cofactor:Magnesium., function:Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D, L-threo-dihydrosphingosine, N, N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol., similarity:Contains 1 DAGKc domain., subunit:Interacts with ACY1 (By similarity) . Binds to calmodulin. Interacts with SPHKAP., tissue specificity:Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle.