MAP3K2 (Phospho-Ser520) Rabbit Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-524., function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity) . Plays a role in caveolae kiss-and-run dynamics., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 OPR domain., similarity:Contains 1 protein kinase domain., subcellular location:Upon EGF stimulation, translocates into the nucleus., subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.