MAP3K2 (Phospho-Ser520) Rabbit Polyclonal Antibody
Product Specifications
Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by phosphorylation on Thr-524., function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity) . Plays a role in caveolae kiss-and-run dynamics., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily., similarity:Contains 1 OPR domain., similarity:Contains 1 protein kinase domain., subcellular location:Upon EGF stimulation, translocates into the nucleus., subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.
Product Name Alternative
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Gene Name
MAP3K2 MAPKKK2 MEKK2
Gene ID
10746
Swiss Prot
Q9Y2U5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Purification
Affinity purification
Dilution
WB 1:500-1:2000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Phosphorylated
Molecular Weight
68kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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