LAB (Phospho-Tyr136) Rabbit Polyclonal Antibody

Disease:Defects in LAT2 may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23., function:Involved in FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor) -mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I) -mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2., PTM:May be polyubiquitinated., PTM:Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2., subcellular location:Present in lipid rafts., subunit:When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL., tissue specificity:Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level) .

Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein)