FKHR (Phospho-Ser249) Rabbit Polyclonal Antibody

Disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13) (q35; q14) with PAX3; translocation t (1;13) (p36; q14) with PAX7. The resulting protein is a transcriptional activator., function:Transcription factor., PTM:Phosphorylated by AKT1; insulin-induced (By similarity) . IGF1 rapidly induces phosphorylation of Ser-256, Thr-24, and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24, and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CK1, leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 fork-head DNA-binding domain., subcellular location:Shuttles between cytoplasm and nucleus., subunit:Interacts with LRPPRC., tissue specificity:Ubiquitous.