RNF138 Rabbit Polyclonal Antibody
Product Specifications
Background
Ring finger protein 138 (RNF138) Homo sapiens The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008], domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme., function:E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway., pathway:Protein modification; protein ubiquitination., PTM:Auto-ubiquitinated., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 RING-type zinc finger., subunit:Interacts with nlk.
Product Name Alternative
RNF138; NARF; HSD-4; HSD4; E3 ubiquitin-protein ligase RNF138; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; hNARF; RING finger protein 138
Gene Name
RNF138
Gene ID
51444
Swiss Prot
Q8WVD3
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:50-1:300
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
28kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
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