Calpain 11 Rabbit Polyclonal Antibody

Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008], catalytic activity:Broad endopeptidase specificity., function:Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction., similarity:Belongs to the peptidase C2 family., similarity:Contains 1 calpain catalytic domain., similarity:Contains 2 EF-hand domains., subunit:Heterodimer of a large (catalytic) and a small (regulatory) subunit., tissue specificity:Highest expression in testis.