NCX1 Rabbit Polyclonal Antibody

In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) concentration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane) . During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) -Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004], alternative products:Additional isoforms seem to exist, enzyme regulation:By ATP., function:Rapidly transports Ca (2+) during excitation-contraction coupling. Ca (2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores., similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily., similarity:Contains 2 Calx-beta domains., tissue specificity:Cardiac sarcolemma.

Calcium; Cardiac muscle contraction; Hypertrophic cardiomyopathy (HCM) ; Arrhythmogenic right ventricular cardiomyopathy (ARVC) ; Dilated cardiomyopathy