SIRT3 Rabbit Polyclonal Antibody

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008], catalytic activity:NAD (+) + an acetylprotein = nicotinamide + O-acetyl-ADP-ribose + a protein., cofactor:Binds 1 zinc ion per subunit., function:NAD-dependent deacetylase. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo., PTM:Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity., similarity:Belongs to the sirtuin family., similarity:Contains 1 deacetylase sirtuin-type domain., tissue specificity:Widely expressed.