TSG-6 Rabbit Polyclonal Antibody

The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010], function:Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis., induction:By TNF., similarity:Contains 1 CUB domain., similarity:Contains 1 Link domain., subunit:Interacts with inter-alpha-inhibitor (I-alpha-I) . Chondroitin sulfate may be required for the stability of the complex., tissue specificity:Found in the synovial fluid of patients with rheumatoid arthritis.

TNFAIP6; TSG6; Tumor necrosis factor-inducible gene 6 protein; Hyaluronate-binding protein; TNF-stimulated gene 6 protein; TSG-6; Tumor necrosis factor alpha-induced protein 6; TNF alpha-induced protein 6