Dvl-2 Rabbit Polyclonal Antibody

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008], function:May play a role in the signal transduction pathway mediated by multiple Wnt genes., PTM:Phosphorylated., similarity:Belongs to the DSH family., similarity:Contains 1 DEP domain., similarity:Contains 1 DIX domain., similarity:Contains 1 PDZ (DHR) domain., subunit:Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity) . Interacts with DIXDC1 and Rac.