Dvl-2 Rabbit Polyclonal Antibody
Product Specifications
Background
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008], function:May play a role in the signal transduction pathway mediated by multiple Wnt genes., PTM:Phosphorylated., similarity:Belongs to the DSH family., similarity:Contains 1 DEP domain., similarity:Contains 1 DIX domain., similarity:Contains 1 PDZ (DHR) domain., subunit:Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity) . Interacts with DIXDC1 and Rac.
Product Name Alternative
DVL2; Segment polarity protein dishevelled homolog DVL-2; Dishevelled-2; DSH homolog 2
Gene Name
DVL2
Gene ID
1856
Swiss Prot
O14641
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ICC/IF, ELISA
Field of Research
WNT; WNT-T CELLNotch; Melanogenesis; Pathways in cancer; Colorectal cancer; Basal cell carcinoma
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:100-1:300, ICC/IF 1:50-1:200, ELISA 1:20000-1:40000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
80kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG
Available Sizes
Curated Selection
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