UHRF1 Rabbit Polyclonal Antibody

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014], developmental stage:Expressed in fetal thymus, liver and kidney., domain:The RING finger is required for ubiquitin ligase activity., domain:The YDG domain mediates the interaction with histone H3., function:Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability., induction:Up-regulated in proliferating cells, and down-regulated in quiescent cells. Down-regulated upon adriamycin-induced DNA damage, in a TP53/p53 and CDKN1A-dependent way. Induced by E2F1 transcription factor., pathway:Protein modification; protein ubiquitination., PTM:Phosphorylated on serine residues. Phosphorylation may enhance DNA-binding activity., PTM:Ubiquitinated; which leads to proteasomal degradation. Polyubiquitination may be stimulated by DNA damage., similarity:Contains 1 PHD-type zinc finger., similarity:Contains 1 ubiquitin-like domain., similarity:Contains 1 YDG domain., similarity:Contains 2 RING-type zinc fingers., subunit:Interacts with histones H3, H1 and H2B (By similarity) . Interacts with HDAC1, but not with HDAC2. Interacts with UHRF1BP1. Binds methylated CpG containing oligonucleotides., tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer.

UHRF1; ICBP90; NP95; RNF106; E3 ubiquitin-protein ligase UHRF1; Inverted CCAAT box-binding protein of 90 kDa; Nuclear protein 95; Nuclear zinc finger protein Np95; HuNp95; hNp95; RING finger protein 106; Transcription factor ICBP90; Ubiquitin-like PHD and RING finger domain-containing protein 1; hUHRF1; Ubiquitin-like-containing PHD and RING finger domains protein 1