IL-31Rα Rabbit Polyclonal Antibody

The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR) . Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011], function:Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity., induction:Up-regulated in lesional keratinocytes of patients with atopic dermatitis. Up-regulated by IFNG and lipopolysaccharides., PTM:N-glycosylated., similarity:Belongs to the type I cytokine receptor family. Type 2 subfamily., similarity:Contains 5 fibronectin type-III domains., subunit:Heterodimer with OSMR. Interacts with JAK1 and STAT3., tissue specificity:Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea and skin. Detected in all of the myelomonocytic lineage. Expressed in CD14-and CD56-positive blood cells and by macrophages (at protein level) .

IL31RA; CRL3; GPL; Interleukin-31 receptor subunit alpha; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; Cytokine receptor-like 3; GLM-R; hGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; ZcytoR17