GCKR Rabbit Polyclonal Antibody

This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY) . [provided by RefSeq, Jul 2008], function:Inhibits glucokinase by forming an inactive complex with this enzyme., similarity:Belongs to the GCKR family., similarity:Contains 1 SIS domain., tissue specificity:Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen.