Cdc42EP3 Rabbit Polyclonal Antibody

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012], function:Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts., similarity:Belongs to the BORG/CEP family., similarity:Contains 1 CRIB domain., subunit:Interacts with RHOQ and CDC42, in a GTP-dependent manner, and with SEPT7., tissue specificity:Highly expressed in the heart and weakly in the brain.