T2R16 Rabbit Polyclonal Antibody

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008], function:Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5., miscellaneous:Confers bitter perception of salicin to non-taster mice., miscellaneous:Several bitter taste receptors are expressed in a single taste receptor cell., polymorphism:The Lys-172 polymorphism in TAS2R16 is associated with genetic susceptibility to alcoholism [MIM:103780]., similarity:Belongs to the G-protein coupled receptor T2R family., tissue specificity:Expressed in a subset of gustducin-positive taste receptor cells of the tongue.