CHP Rabbit Polyclonal Antibody

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008], function:Required for constitutive membrane traffic. Inhibits GTPase-stimulated Na (+) /H (+) exchange. Also inhibits calcineurin phosphatase activity. Required for activity of SLC9A1/NHE1., PTM:Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic., PTM:Phosphorylated; decreased phosphorylation is associated with an increase in exchange activity. The phosphorylation state may regulate the binding to NHE1., similarity:Contains 4 EF-hand domains., subunit:Monomer (By similarity) . Specifically binds to SLC9A1/NHE1 at a domain that is critical for growth factor stimulation of exchange activity., tissue specificity:Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.

CHP1; CHP; Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22

MAPK_ERK_Growth; MAPK_G_Protein; Calcium; Oocyte meiosis; Apoptosis_Inhibition; Apoptosis_Mitochondrial; Apoptosis_Overview; WNT; WNT-T CELLAxon guidance; VEGF; Natural killer cell mediated cytotoxicity; T_Cell_Receptor; B_Cell_Antigen; Long-term potentiation; Alzheimer's disease; Amyotrophic lateral sclerosis (ALS)