NHERF-2 Rabbit Polyclonal Antibody

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011], function:Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus., similarity:Contains 2 PDZ (DHR) domains., subcellular location:Nuclear, in a punctate pattern., subunit:Homodimer, and heterodimer with SLC9A3R1. Binds PODXL and PDZK1 (By similarity) . Binds ADRB2, SLC9A3, P2RY1, P2YR2, SRY, RDX and LPAR2., tissue specificity:Widely expressed.

SLC9A3R2; NHERF2; Na (+) /H (+) exchange regulatory cofactor NHE-RF2; NHERF-2; NHE3 kinase A regulatory protein E3KARP; SRY-interacting protein 1; SIP-1; Sodium-hydrogen exchanger regulatory factor 2; Solute carrier family 9 isoform A3 regulatory factor 2; Tyrosine kinase activator protein 1; TKA-1